Respected Money Breakdown: 49ers vs Rams

Expert analysis and top fantasy picks by @respectedmoney for the 49ers vs Rams Week 5 clash.

Updated: October 2, 2025, 12:24 PM EDT | Brought to you by @respectedmoney, one of the top Vegas insiders in the country.

Week 5 of the 2025 season kicks off on Thursday Night with a pivotal clash between the 49ers (3-1) and Rams (3-1) in a battle for first place in the NFC West.

TOP PLAYS

RB Kyren Williams – Over 16.5 Rushing Attempts (-124)

Williams, who is the overall RB18 in PPR scoring formats, projects as a workhorse back on Thursday night. Fantasy managers should fire up the veteran back as a solid RB1 with confidence, despite playing on the short week. A deeper dive reveals that Sean McVay and the Rams have historically leaned heavily on Williams against San Francisco. In three career games versus the 49ers the fourth-year back has posted 67 carries for 249 yards with five total touchdowns. Averaging 22.3 rushing attempts in those tilts, we will invest in over his 16.5 rushing attempts – against a 49ers defense that is allowing 4.1 yards per rush to opposing running backs through four games.

WR – Davante Adams Anytime Touchdown (+115)

Adams has quickly emerged as a favorite target of Matthew Stafford in his first season with Rams – scoring in three consecutive games. The veteran WR, who has scored 106 touchdowns in 168 career games, offers solid value at plus-odds to extend his scoring streak on Thursday night. Scoring at an absurd 68% clip in his illustrious career, let’s invest in a WR who ranks first among all wideouts in the NFL in red zone targets (10) and sixth in overall targets (35) – to find paydirt for the fourth consecutive week.

WR – Davante Adams Over 54.5 Receiving Yards (-116)

As we highlighted above, Adams has made an immediate impact with Los Angeles and it leads to the need for a double-pop investment on his receiving yards. Adams, who has surpassed this projection in three straight games, has eclipsed this receiving yards demand in 9 of his last 11 games dating back to last season. Expect the savvy veteran, who has had 74 receptions for 1,009 yards and 8 touchdowns in 13 games on Thursday night games in his career, to add to those gaudy Prime Time numbers.

Vegas vs FullTime Projections Performance

Thus far, Respected Money projections are off to a red-hot start:

• ✅Week 1: 5-6 (+6.15 UNITS)📈
• ✅Week 2: 7-10 (+7.25 UNITS)📈
• ✅Week 3: 4-1 (+4.3 UNITS)📈
• ✅Week 4: 3-6 (-1.95 UNITS)
• 🔥Overall YTD: 19-23 (+15.75 UNITS)📈

For real-time updates and the full projection file, members can download from the DOWNLOADS page. Stay tuned as our analysts adjust projections throughout the game!