The first game of the 2022 NFL season didn't quite live up to the hype. At least not for the defending champions. The second week begins with an exciting AFC West matchup between the Chargers and Chiefs that should make up for the Rams' disappointing showing. Our Thursday Night Football Preview: Week 2 will gives you all the fantasy football, DFS, and sports betting tips you'll need. Both squads enter this tilt 1-0 after impressive victories in their openers. The Chiefs have won 13 of their last 16 matchups with the Chargers and shootouts have been the norm of late. This should be another exciting, high-scoring grudge match. Let's break down the fantasy football ramifications in our Thursday Night Football Preview: Week 2. They face another tough task in Week 2, traveling to Arrowhead on a short week. Matchup   

TEAM	OFFENSE	PASS	RUSH	YDS/PLAY	POINTS
Los Angeles Chargers	2	1	11	1	1
Kansas City Chiefs	9	8	24	16	9

* above ranks are from the 2021 season Kansas City dismantled the Cardinals in Arizona last week behind a league-best 360 passing yards and five touchdowns from Patrick Mahomes. This quelled any concerns of how Andy Reid and company with fare after trading away Tyreek Hill in the offseason. Andy Reid found success by distributing the ball among multiple players. Mahomes had completed passes to nine different teammates in the first half of the team's blowout win. Meanwhile, Brandon Staley's Chargers come off of a 24-19 road victory against the Raiders. Behind another solid outing from QB Justin Herbert, LA did just enough to keep Derek Carr and the Raiders from mounting a successful comeback in Las Vegas. Four of the last five meetings between these two AFC West rivals have gone over 52 points, so there should be plenty of fireworks. This is the first NFL game to be available exclusively on a streaming platform, so it should be a memorable contest on multiple fronts. Kansas City enters Week 2 as four-point favorites and the over/under is set at a whopping 54 points. This game certainly doesn't look like another boring Thursday Night tilt. There should be plenty of points scored and that means a ton of fantasy football ramifications.   How will tonight's Chargers vs Chiefs game go?

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